Autopista La Tinaja - Cosoleacaque, Carretera Matehuala-Saltillo
1,806 km19 hours 55 mins
| Head southwest on Calle 5 de Mayo | 1 km | |
| Turn left onto Rivera del Rio Seco | 113 m | |
| Continue onto Paraíso - Comalcalco | 16 km | |
| Keep left at the fork | 971 m | |
| Continue onto Boulevard Adolfo López Mateos | 4 km | |
| Continue onto Avenida Lázaro Cárdenas Del Río | 36 km | |
| Make a slight left | 631 m | |
| Take the ramp on the left | 54 m | |
| Merge left onto Carretera Coatzacoalcos - Villahermosa (MEX 180) | 6 km | |
| Keep right onto Carretera Coatzacoalcos - Villahermosa (MEX 180) | 11 km | |
| Keep left onto MEX 180D | 96 km | |
| Keep right onto MEX 180D | 22 km | |
| Continue onto Autopista La Tinaja - Cosoleacaque (MEX 145D) | 145 km | |
| Make a slight left onto Autopista La Tinaja - Cosoleacaque (MEX 145D) | 84 km | |
| Merge left onto Autopista Veracruz - México (MEX 150D W) | 31 km | |
| Keep right onto Autopista Veracruz - México (MEX 150D W) | 29 km | |
| Keep left onto MEX 150D W | 68 km | |
| Merge left onto MEX 150D | 13 km | |
| Keep left onto MEX 150D | 24 km | |
| Continue onto Autopista Puebla-Orizaba (MEX 150D) | 39 km | |
| Keep straight onto Autopista Puebla-Orizaba (MEX 150D) | 14 km | |
| Keep right onto MEX 150D | 111 km | |
| Take the ramp | 32 m | |
| Merge right onto Autopista México Puebla | 390 m | |
| Continue onto Calzada General Ignacio Zaragoza | 10 km | |
| Keep right onto Calzada General Ignacio Zaragoza | 2 km | |
| Exit the roundabout onto Calzada General Ignacio Zaragoza | 721 m | |
| Continue onto Avenida Calzada General Ignacio Zaragoza | 2 km | |
| Keep right at the fork | 221 m | |
| Merge left onto Avenida Ingeniero Eduardo Molina (3O) | 2 km | |
| Turn left onto Avenida Río Consulado | 46 m | |
| Turn left onto Avenida Ingeniero Eduardo Molina (3 OTE) | 15 m | |
| Turn right onto Circuito Interior (INT) | 3 km | |
| Take the ramp | 42 m | |
| Go straight onto Avenida Río Consulado | 81 m | |
| Make a slight right onto Calle Paganini | 775 m | |
| Continue onto Paganini | 225 m | |
| Merge right onto Lázaro Cárdenas (Eje Central) | 5 km | |
| Continue onto Eje Vial Central (C) | 1 km | |
| Keep left onto Eje Vial Central | 273 m | |
| Continue onto Calle Río Tlanepantla (P) | 227 m | |
| Make a slight right | 50 m | |
| Go straight onto Mario Colín (Periférico) | 2 km | |
| Make a slight right onto Avenida Jesús Reyes Heroles | 448 m | |
| Turn left onto Avenida Jesús Reyes Heroles | 4 km | |
| Continue onto Del Durazno | 5 km | |
| Continue onto Periférico (MEX 57) | 294 m | |
| Continue onto México-Queretaro (MEX 57) | 14 km | |
| Continue onto Autopista de Peaje México-Queretaro (MEX 57D) | 18 km | |
| Continue onto México-Queretaro (MEX 57D) | 8 km | |
| Continue onto Carretera de Cuota México-Queretaro (MEX 57D) | 69 km | |
| Continue onto Autopista de Peaje México-Queretaro (MEX 57D) | 10 km | |
| Keep left onto Autopista de Peaje México-Queretaro (MEX 57D) | 2 km | |
| Continue onto Supercarretera México-Queretaro (MEX 57) | 43 km | |
| Take the ramp | 69 m | |
| Keep left at the fork | 977 m | |
| Continue onto Libramiento Ciudad de México-San Luis Potosí (MEX 57D) | 36 km | |
| Keep left at the fork | 314 m | |
| Keep right at the fork | 400 m | |
| Merge left onto Carretera Querétaro - San Luis Potosí (MEX 57) | 139 km | |
| Continue onto Carretera Querétaro-San Luis Potosí (MEX 57) | 18 km | |
| Take the ramp | 430 m | |
| Merge left onto Libramiento San Luis Potosi (MEX 57D) | 33 km | |
| Merge right onto Carretera San Luis Potosí-Matehuala (MEX 57) | 7 km | |
| Continue onto Carr. San Luis Potosi - Matehuala (MEX 57) | 9 km | |
| Continue onto Carretera San Luis Potosi-Matehuala (MEX 57) | 141 km | |
| Keep right onto Libramiento de Matehuala (MEX 57D) | 14 km | |
| Merge right onto Carretera Matehuala-Saltillo (MEX 57) | 192 km | |
| Continue onto Autopista de Peaje Puerto México-Ojo Caliente (MEX 57D) | 55 km | |
| Take the ramp | 969 m | |
| Merge left onto Carretera Saltillo-Monterrey (MEX 40) | 5 km | |
| Take the ramp | 1 km | |
| Merge left onto Autopista de Peaje Saltillo-Monterrey (MEX 40D) | 27 km | |
| Keep right onto Salida Anillo Periferico | 1 km | |
| Keep left onto Periférico Monterrey | 395 m | |
| Keep left onto Periférico Monterrey (1610) | 17 km | |
| Continue onto Periferico Monterrey (1610) | 5 km | |
| Continue onto Periférico Monterrey (1610) | 6 km | |
| Continue onto Periferico Monterrey (1610) | 9 km | |
| Continue onto Periférico Monterrey (1610) | 141 m | |
| Take the ramp on the left | 559 m | |
| Merge left onto Carretera Monterrey-Nuevo Laredo (MEX 85) | 79 km | |
| Take the ramp | 309 m | |
| Go straight onto NL 2 | 51 km | |
| Turn right onto Calle Zaragoza | 59 m | |
| You have arrived at your destination, on the left |
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