MEX 180, Calica - Cozumel
902 km14 hours 7 mins
| Head north | 74 m | |
| Turn right | 616 m | |
| Turn right onto Circumbalación 2 | 7 km | |
| Turn left onto Villahermosa - Chetumal 186 (MEX 186) | 61 km | |
| Continue onto A Catazajá | 131 m | |
| Go straight onto Carretera Catazajá - Pakalná (MEX 199) | 511 m | |
| Turn right onto Carretera Villahermosa-Francisco Escárcega (MEX 186) | 31 km | |
| Keep right onto Carretera Villahermosa-Francisco Escárcega (MEX 186) | 129 km | |
| Turn left onto Carretera Díaz Ordaz-Sabancuy (MEX 259) | 138 m | |
| Go straight onto Carretera Sabancuy-Díaz Ordaz (MEX 259) | 18 km | |
| Continue straight to stay on Carretera Sabancuy-Díaz Ordaz (MEX 259) | 37 km | |
| Go straight onto Manuel J. López Hernández (MEX 259) | 742 m | |
| Make a slight left to stay on Manuel J. López Hernández (MEX 259) | 183 m | |
| Continue onto Carretera Sabancuy-Díaz Ordaz (MEX 259) | 2 km | |
| Keep left onto MEX 259 | 54 m | |
| Make a sharp right onto Carretera Ciudad del Carmen-Campeche (MEX 180) | 43 km | |
| Continue straight to stay on Carretera Ciudad del Carmen-Campeche (MEX 180) | 14 km | |
| Go straight onto MEX 180 | 6 km | |
| Enter the roundabout and take the 2nd exit onto Avenida Carlos Sansores Pérez (MEX 180) | 35 m | |
| Exit the roundabout onto Avenida Carlos Sansores Pérez (MEX 180) | 2 km | |
| Go straight onto Avenida Revolución (MEX 180) | 18 km | |
| Continue onto Autopista de Peaje Champotón-Campeche (MEX 180D) | 39 km | |
| Take the ramp | 305 m | |
| Continue onto Libramiento de Campeche (MEX 180) | 2 km | |
| Keep left onto Libramiento de Campeche (MEX 180) | 21 km | |
| Keep right onto MEX 180 | 136 km | |
| Go straight onto MEX 180 | 7 km | |
| Merge left onto Anillo Periférico Licenciado Manuel Berzunza | 14 km | |
| Take the ramp | 396 m | |
| Enter the roundabout and take the 1st exit onto MEX 180 | 12 m | |
| Exit the roundabout onto MEX 180 | 14 km | |
| Go straight onto MEX 180 | 35 km | |
| Take the ramp | 142 m | |
| Keep left at the fork | 647 m | |
| Continue onto MEX 180 | 10 km | |
| Keep left onto MEX 180 | 172 km | |
| Take the ramp onto MEX 305D | 455 m | |
| Merge left onto Ramal a Playa del Carmen (MEX 305D) | 43 km | |
| Continue onto Avenida Luis Donaldo Colosio | 5 km | |
| Turn right onto 115 Avenida | 4 km | |
| Enter the roundabout and take the 6th exit onto Avenida 41 Sur | 151 m | |
| Exit the roundabout onto Avenida 41 Sur | 748 m | |
| Enter the roundabout and take the 2nd exit onto Calle 41 Sur | 22 m | |
| Exit the roundabout onto Calle 41 Sur | 691 m | |
| Turn right onto Carretera Federal (MEX 307) | 6 km | |
| Turn left | 2 km | |
| Take the ferry Calica - Cozumel | 20 km | |
| Continue slight left | 206 m | |
| Turn right | 42 m | |
| Turn right onto Avenida Rafael E. Melgar (MEX C1) | 429 m | |
| Turn left onto Calle 5 Sur | 2 km | |
| Turn right onto Avenida. 8 De Octobre | 104 m | |
| Turn right onto Calle Miguel Hidalgo | 64 m | |
| You have arrived at your destination, on the left |
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